The 5-HT1A Receptor in Psychopharmacology
نویسنده
چکیده
The 5-HT 1A receptor is a subtype of serotonin receptor located in presynaptic and postsynaptic regions. Activation of this receptor has been involved in the mechanism of action of anxiolytic, antidepressant and antipsychotic medications. Serotonin is a monoamine neurotransmitter that interacts with 14 serotonin (5-HT) receptors that can be subdivided into 7 classes [1]. Specifically, the 5-HT 1A receptors are G-protein coupled receptors that exert their effects through Gi/o proteins to inhibit adenylyl cyclase, as well as other second messenger cascades such as MAPK pathways and NMDA receptor channels [2].
منابع مشابه
Involvement of the 5-HT1A receptor of the cuneiform nucleus in the regulation of cardiovascular responses during normal and hemorrhagic conditions
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